AI is reshaping how work gets done—and how risks emerge across cloud, data, identity, and more. Many organizations want AI-powered productivity, but their security foundations aren’t yet built for it. As organizations move toward AI-powered operating models, security becomes the critical enabler to allow innovation to scale responsibly. In this new era of agentic AI,¹ protections can’t be layered on after the fact; they must be built into the fabric of how AI systems are developed, governed, and used—grounded in strong cloud security posture, clear data governance, and Zero Trust principles that assume breach and verify continuously.  We’re sharing two customer spotlights that explore how global organizations are putting that approach into practice.

Why security has become a strategic enabler for AI‑powered growth 

These customer stories highlight how security is no longer a supporting function—it’s a strategic enabler of growth, speed, and trust. As AI accelerates decision-making and reshapes how work gets done, leaders must modernize without increasing risk or slowing the business. The experiences of these forward-looking organizations reflect the realities many companies face: gaining consistent visibility across complex environments, moving faster while maintaining trust, meeting governance and compliance expectations that expand with AI adoption, and driving operational efficiency through automation. These examples will show how the right security foundation allows organizations to scale AI with confidence—turning protection into a competitive advantage, not a constraint.  

First, we’ll take a closer look at St. Luke’s University Health Network. 

How St. Luke’s is accelerating efficiency and threat response with AI 

St. Luke’s identified a critical gap in unified, real-time visibility across its security tools, limiting its ability to detect and stop threats early. The organization needed a way to see across their entire landscape and respond to threats as they emerge. To modernize and unify security operations, St. Luke’s turned to Microsoft Security Copilot to supercharge analyst productivity and help its Security Operations Center (SOC) teams operate at scale. 

By connecting Microsoft Defender and Microsoft Sentinel, St. Luke’s gains a single, AI-powered view across endpoints, identity, email, and cloud workloads—helping analysts move faster, correlate cyberthreats more effectively, and shift from reactive response to proactive, predictive defense. With AI embedded directly into daily workflows, teams can identify risks in real time, uncover gaps in visibility, and make more informed decisions with greater precision.

Streamlining workflows and automating protection

At the same time, Security Copilot agents are transforming how the SOC operates by automating time-consuming tasks like alert triage and vulnerability remediation. This reduces noise, accelerates investigations, and frees analysts to focus on real threats and strategic work. The result is a more efficient, collaborative, and resilient security operation built for today’s increasingly complex threat landscape. With Microsoft Security Copilot, St. Luke’s has:

• Unified visibility across Defender and Microsoft Sentinel eliminates silos and accelerates threat response.
• AI-powered insights help analysts detect, investigate, and act on cyberthreats in real time.
• Security Copilot agents automating routine tasks, with Security Triage Agent saving up to 200 analyst hours each month.
• Advanced phishing triage reduces false positives and improves decision confidence.
• Centralized workflows improve collaboration, reporting speed, and overall SOC efficiency.

St. Luke’s sees its investment in Security Copilot as the foundation for a self-improving security ecosystem. AI-powered security means the team stays ahead of both technological and business changes, ensuring that St. Luke’s remains resilient in the face of evolving threats. To learn more about how St. Luke’s is modernizing and unifying security operations with Microsoft Security Copilot, watch the customer video or read the full St. Luke’s customer story.

How ManpowerGroup is securing a global workforce with a unified platform 

ManpowerGroup is modernizing toward a unified, cloud-based security platform to protect a highly distributed workforce, addressing identity-centric risk and complex compliance requirements as AI becomes embedded in everyday work. Their experiences show how organizations can use Microsoft Security to secure the foundation of AI transformation, end to end. 

As ManpowerGroup scaled globally, its longstanding mix of security tools became more difficult to manage, driving complexity, inconsistent controls, and slower response as cyberthreats and regulatory demands increased. 

To reduce tool sprawl, ManpowerGroup deployed Microsoft 365 E5 for the real-time identity, endpoint, email, and cloud prevention, detection, and response capabilities of Microsoft Defender, plus the cloud-native security information and event management (SIEM) and security orchestration, automation, and response (SOAR) performance of Microsoft Sentinel. 

By deploying Microsoft 365 E5, ManpowerGroup reduced security complexity, cut integration timelines from weeks or months to hours or days, unified global security operations, and built an AI-ready security foundation. To see how this platform approach is supporting secure, agile operations worldwide, watch the customer video read the full ManpowerGroup story. 

A repeatable playbook for securing AI at scale 

While these customers operate in very different environments, their paths to securing their organization and adopting (or preparing to adopt) AI followed the same core pattern—one that other organizations can adopt as they modernize. Both started by anchoring security decisions in business risk, then unified signals across cloud, data, identity, and operations, and finally automated guardrails so protection could scale alongside AI-powered work. These experiences point to a clear, repeatable approach for security and adopting AI without slowing business: 

• Lead with risk and business value. Clearly define what must be protected—and why—so security enables AI adoption rather than constraining it. 
• Unify visibility across the environment. Connect cloud, identity, data, and security operations (SecOps) signals into a single operational view to reduce blind spots. 
• Make governance real, not aspirational. Operationalize classification, labeling, data loss prevention, and policy enforcement, so protections are consistent by default. 
• Harden posture continuously. Use continuous configuration management and drift detection to prevent misconfigurations as environments evolve. 
• Automate outcomes at scale. Streamline response and compliance reporting so security and governance improve without increasing headcount. 

This approach helped both organizations move faster with confidence—and offers a practical blueprint for others looking to secure the foundation of AI transformation. 

What Frontier firms get right in the AI era 

These stories point to a broader pattern emerging among leading organizations. “Frontier firms” refers to organizations that lead in the AI era by pairing speed with trust. They move quickly—but not recklessly—because security is treated as a foundational capability, not an afterthought. For these organizations, protection is built into how work gets done: governance that scales as AI adoption grows, posture that remains resilient as environments change, and controls that operate continuously in the background. Security becomes the primitive that allows AI to be deployed with confidence, not constraint. 

These customers exemplify what this looks like in practice. And through their stories, we gain a playbook that other organizations can deploy with confidence. By modernizing security as a platform—connecting visibility, governance, posture management, and automation—organizations can enable AI-powered work while strengthening trust across data, identities, cloud environments, and more. These customer stories show that in the AI era, organizations that treat security as a strategic foundation will be best positioned to lead, adapt, and compete in an AI-powered world. Learn more about how Microsoft Security helps organizations secure AI-powered work at scale. 

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¹Secure agentic AI for your Frontier Transformation, Microsoft Security blog. March 9, 2026.