Too Long; Didn't Read
The broad range of tools for fitting mutational signatures makes it difficult to understand which tool to choose for a given project. We find that flat signatures whose average similarity with other signatures is high are the most difficult to fit. The common practice of excluding signatures from the reference catalog because they do not seem to be active is little effective or even harmful.
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Mutation: process of changing in form or nature. We publish the best academic journals & first hand accounts of Mutation
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